2008-2018 Ten years’ service to the pharma and biotech industries

Who we are

Norman Miller Selected publications


Books edited

Gotto AM Jr, Miller NE, Oliver MF
High density lipoproteins and atherosclerosis. Amsterdam: Elsevier/North-Holland, 1978.
Miller NE, Lewis B
Lipoproteins, atherosclerosis and coronary heart disease. Amsterdam: Elsevier/North-Holland, 1981
Miller NE
Atherosclerosis: Mechanisms and approaches to therapy. New York: Raven, 1984
Miller NE, Miller GJ
Clinical and metabolic aspects of high-density lipoproteins. Amsterdam: Elsevier/North-Holland, 1985
Fears R, Levy RI, Miller NE, Shepherd J, Packard CJ
Pharmacological control of hyperlipidaemia. Barcelona: Prous Science, 1986
Miller NE
High density lipoproteins and atherosclerosis II. Amsterdam: Elsevier, 1989
Miller NE
High density lipoproteins, reverse cholesterol transport and coronary heart disease. Amsterdam: Excerpta Medica, 1989
Poulik MD, Peeters H, Hobbs JR, Mestecky J, Miller NE
Protides of the biological fluids. Volume 36: Lipoproteins, IgG and IgA subclasses, and cytofluorimetry. Oxford: Pergamon Press, 1989
Miller NE, Tall AR
High density lipoproteins and atherosclerosis III. Amsterdam: Excerpta Medica, 1992

Review articles

Miller GJ, Miller NE
Plasma high-density-lipoprotein concentration and development of ischaemic heart-disease
Lancet 1975; 1: 16-19
Nicoll A, Miller NE, Lewis B
High-density lipoprotein metabolism
Adv Lipid Res 1980; 17: 53-106
Miller NE
Why does the plasma low-density lipoprotein concentration in adults increase with age?
Lancet 1984; 1: 263-266
Reichl D, Miller NE
The anatomy and physiology of reverse cholesterol transport
Clin Sci 1986; 70: 221-31
Godsland IF, Wynn V, Crook D, Miller NE
Sex, plasma lipoproteins and atherosclerosis: prevailing assumptions and outstanding questions.
Am Heart J 1987; 114: 1467-503
Miller NE.
Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosis
Am Heart J 1987;113 (No 2, pt 2):589-97
Miller NE
On the associations of body cholesterol pool size with age, HDL cholesterol and plasma total cholesterol concentration in humans
Atherosclerosis 1987; 67: 163-72
Reichl D, Miller NE
Pathophysiology of reverse cholesterol transport: insights from inherited disorders of lipoprotein metabolism
Arteriosclerosis 1989; 9: 785-97
Miller NE
Raising high density lipoprotein cholesterol: the biochemical pharmacology of reverse cholesterol transport
Biochem Pharmacol. 1990; 40:403-10
Miller NE
High density lipoprotein-raising drugs as anti-atherogenic agents
Current Opinions in Therapeutic Patents. 1991; 1:567-574
Miller NE, Nanjee MN, Miller IP, Brinton EA
Effects of intravenous apo A-I, HDLs and apo A-I/phospholipid discs on vascular metabolism and atherosclerosis in animals and humans
Curr Med Chem 2005; 5:315-20
Randolph GJ, Miller NE
Lymphatic transport of high-density lipoproteins and chylomicrons.
J Clin Invest. 2014; 124: 929-35
Kingwell BA, Chapman MJ, Kontush A, Miller NE
HDL-targeted therapies : progress, failures and future
Nature Rev Drug Disc 2014; 13: 445-64
Miller NE.
CETP inhibitors and cardiovascular disease: time to think again.
F1000 Research 2014; 3: 124 (doi: 10.12688/f1000research.4396.1)
Miller NE
Alipogene tiparvovec: gene therapy for familial lipoprotein lipase deficiency. In: Gene and Cell Therapy
4th edition. CRC Press, New York. pp 983-99. Ed, NS Templeton
Miller NE
Cholesteryl ester transfer protein: ace of spades, queen of hearts, or the joker? Front Pharmacol. doi. 10.3389/fphar.2015.00145. Pubmed ID 26236237.

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Metabolism - cellular

Miller NE, Weinstein DB, Steinberg D
Binding, internalization, and degradation of high density lipoprotein by cultured normal human fibroblasts.
J Lipid Res 1977; 18:438-450
Miller NE, Weinstein DB, Carew TE, Koschinsky T, Steinberg D
Interaction between high density and low density lipoproteins during uptake and degradation by cultured human fibroblasts
J Clin Invest 1977; 60:78-88
Miller NE, Weinstein DB, Steinberg D
Uptake and degradation of high density lipoprotein: comparison of fibroblasts from normal subjects and from homozygous familial hypercholesterolemic subjects
J Lipid Res 1978; 19: 644-653
Cockerill GW, Saklatvala J, Ridley SH, Yarwood H, Miller NE, Oral B, Nithyanathan S, Taylor G, Haskard DO
High density lipoproteins differentially modulate cytokine-induced expression of E selectin and cyclooxygenase-2
Arterioscler Thromb Vasc Biol 1999; 19:910-917

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Metabolism - experimental

Miller NE, La Ville A, Crook D
Direct evidence that reverse cholesterol transport is mediated by high-density lipoprotein in rabbit
Nature 1985; 314:109-111
Miller NE, Nanjee MN
Evidence that reverse cholesterol transport is stimulated by lipolysis of triglyceride-rich lipoproteins
FEBS Letters 1991; 285:132-134
Cockerill GW, Huehns TY, Weerasinghe A, Stocker C, Lerch PG, Miller NE, Haskard DO
Elevation of plasma high-density lipoprotein concentration reduces interleukin-1 induced expression of E-selectin in an in vivo model of acute inflammation
Circulation 2000; 103:108-112.
Cockerill GW, McDonald MC, Mota-Filipe H, Cuzzocrea S, Miller NE, Thiemermann C
High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock
FASEB Journal. 2001; 15: 1941-1952

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Metabolism - human

Rao SN, Magill PJ, Miller NE, Lewis B
Plasma high-density lipoprotein metabolism in subjects with primary hypertriglycerid-aemia: altered metabolism of apoproteins AI and AII
Clin Sci 1980; 59:359-367
Mistry P, Miller NE, Laker M, Hazzard WR, Lewis B
Individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man: studies of low density lipoprotein receptor activity and 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in blood mononuclear cells
J Clin Invest 1981; 67: 493-502
Nanjee MN, Crouse JR, King JM, Hovorka R, Rees SE, Carson ER, Morgenthaler J-J, Lerch P, Miller NE
Effects of intravenous infusion of lipid-free apolipoprotein A-I in humans
Arterioscler Thromb Vasc Biol. 1996; 16:1203-14
Nanjee MN, Doran JE, Lerch PG, Miller NE
Acute effects of intravenous infusion of apolipoprotein
A-I/phosphatidylcholine discs on plasma lipoproteins in humans.
Arterioscler Thromb Vasc Biol 1999; 19:979-989
Nanjee MN, Cooke CJ, Olszewski WL, Miller NE
Lipid and apolipoprotein concentrations in prenodal leg lymph of fasted humans: associations with plasma concentrations in normal subjects, lipoprotein lipase deficiency and LCAT deficiency
J Lipid Res 2000; 41:1317-1327
Nanjee MN, Cooke CJ, Olszewski WL, Miller NE
Concentrations of electrophoretic and size subclasses of apolipoprotein A-I containing particles in human peripheral lymph
Arterioscler Thromb Vasc Biol. 2000; 20:2148-2155
Oka T, Kujiraoka T, Ito M, Egashira T, Takahashi S, Nanjee MN, Miller NE, Metso J, Olkkonen VM, Ehnholm C, Jauhiainen M, Hattori H
Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive
J Lipid Res 2000;41:1651-1657
Nanjee M N, Cooke CJ, Wong J, Hamilton RL, Olszewski WL, Miller NE
Composition and ultrastructure of size subclasses of normal human peripheral lymph lipoproteins: Quantification of cholesterol uptake by HDLs in tissue fluids
J Lipid Res 2001; 42:639-648
Nanjee MN, Cooke CJ, Garvin R, Semeria F, Lewis G, Olszewski WL, Miller NE
Intravenous apo A-I/lecithin discs increase pre-beta HDL concentration in tissue fluid and stimulate reverse cholesterol transport in humans.
J Lipid Res. 2001; 42: 1586-1593
Navab M, Hama SY, Cooke CJ, Ananthramaiah GM, Chaddha M, Jin L, Subbanagounder G, Faull KF, Reddy S, Miller NE, Fogelman AM
Normal high density lipoprotein inhibits three steps in the formation of mildly oxidised low density lipoprotein: Step 1
J Lipid Res. 2000; 41:1481-1494
Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, et al
Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.
Am J Physiol - Endocrinol Metab 2011; 301: E659-67
Miller NE, Olszewski WL, Hattori H, Miller IP, Kujiraoka T, et al
Lipoprotein remodelling generates lipid-poor apolipoprotein AI particles in human interstitial fluid.
Am J Physiol - Endocrinol Metab 2013; 304 : E321-E328.
Michel CC, Nanjee MN, Olszewski WL, Miller NE
LDL and HDL transfer rates across peripheral microvascular endothelium agree with those predicted for passive ultrafiltration in humans
J Lipid Res 2015; 56 : 122-128

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Genetics

Law A, Wallis SC, Powell LM, Pease RJ, Brunt H, Priestley LM, Knott TJ, Scott J, Altman DG, Miller GJ, Rajput J, Miller NE
Common DNA polymorphism within coding sequence of apolipoprotein B gene associated with altered lipid levels.
Lancet 1986; 1:1301-1303
Kessling AM, Rajput-Wiliams J, Bainton D, Scott J, Miller NE, Baker I, Humphries SE
DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: a study in men selected for differences in high-density lipoprotein cholesterol concentration.
Amer J Hum Genet 1988; 42:458-467
Rajput-Williams J, Knott TJ, Wallis SC, Sweetnam P, Yarnell J, Cox N, Bell GI, Miller NE, Scott J
Variation of apolipoprotein-B gene is associated with obesity, high blood cholesterol levels and increased risk of coronary heart disease
Lancet 1988; 2:1442-1446
Stocks J, Cooke CJ, Miller NE
A common lecithin:cholesterol acyltransferase gene variant (Ser208Thr)
Atherosclerosis 2000;149: 219-220
Vergnes L, Baroukh N, Ostos MA, Castro G, Duverger N, Nanjee MN, Najib J, Fruchart J-C, Miller NE, Zakin MM, Ochoa A
Expression of the human apolipoprotein A-I/C-III/A-IV gene cluster in mice induces hyperlipidemia but reduces atherogenesis
Arterioscler Thromb Vasc Biol. 2000; 20: 2267-74
Talmud PJ, Hawe E, Robertson K, Miller GJ, Miller NE, Humphries SE
Genetic and environmental determinants of plasma high density lipoprotein cholesterol and apolipoprotein A-I concentrations in healthy middle-aged men
Ann Hum Gen. 2002; 66: 111-24
Recalde D, Baroukh N, Viglietta C, Prince S, Verona J, Vergnes L, Pidoux J, Nanjee MN, Brites F, Ochoa A, Castro G, Zakin MM, Miller NE, Houdebine LM
Human apo A-I/C-III/A-IV gene cluster transgenic rabbits: effects of a high-cholesterol diet.
FEBS Lett 2004; 572: 294-298

Miller NE.
Mendelian randomisation studies of HDL (e-Letter) Eur Heart 2014;  http://eurheartj.oxfordjournals.org/cgi/eletters/eht571v1#2071

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Epidemiology

Miller NE, Fórde OH, Thelle DS, Mjós OD
The Tromsó Heart Study: high-density lipoprotein and coronary heart-disease: a prospective case-control study.
Lancet 1977; 1: 965-968
ISI Citation Classic. Became the third most cited paper ever published in The Lancet.
Miller NE, Hammett F, Saltissi S, Rao S, Van Zeller H, Coltart J, Lewis B
Relation of angiographically defined coronary artery disease to plasma lipoprotein subfractions and apolipoproteins
Br Med J 1981; 282:1741-1744
Bainton D, Miller NE, Bolton CH, Yarnell JWG, Sweetnam PM, Baker IA, Lewis B, Elwood P Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease risk in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies
Br Heart J. 1992; 68:60-66
Sweetnam PM, Bolton CH, Yarnell JWG, Bainton D, Baker IA, Elwood PC, Miller NE
Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies
Circulation 1994; 90:769-774
Yarnell JWG, Patterson CC, Sweetnam PM, Thomas HF, Bainton D, Elwood PC, Bolton CH, Miller NE
Do total and high density lipoprotein cholesterol and triglycerides act independently in the prediction of ischemic heart disease? Ten-year follow-up of Caerphilly and Speedwell cohorts
Arterioscler Thromb Vasc Biol. 2001; 21:1340-5
Hattori H, Kujiraoka T, Egashira T, Saito E, Fujioka T, Takahashi S, Ito M, Cooper JA, Stepanova IP, Nanjee MN, Miller NE
Association of coronary heart disease with pre-beta HDL concentrations in Japanese men
Clin Chem 2004: 50: 589-595

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Clinical trials

Miller NE, Clifton-Bligh P, Nestel PJ
Effects of colestipol, a new bile acid-sequestering resin, on cholesterol metabolism in man
J Lab Clin Med 1973; 82:876-890
Luxton MR, Miller NE, Oliver MF
Antilipolytic therapy in angina pectoris: reduction of exercise-induced ST segment depression
Br Heart J 1976; 38: 1204-1208
Lewis B, Hammett F, Katan M, Kay RM, Merkx I, Nobels A, Miller NE, Swan AV
Towards an improved lipid-lowering diet: additive effects of changes in nutrient intake
Lancet 1981; 2:1310-1313
Duffield RGM, Lewis B, Miller NE, Jamieson CW, Brunt JNH, Colchester ACF
Treatment of hyperlipidaemia retards progression of symptomatic femoral atherosclerosis: a randomized controlled trial
Lancet 1983; 2:639-641
Miller NE, Nanjee MN, Rajput-Williams J, Coltart DJ
Double-blind trial of the long-term effects of acebutolol and propranolol on serum lipoproteins in patients with stable angina pectoris
Am Heart J 1987; 114:1007-1010
King JM, Crouse JR, Terry JG, Morgan TM, Spray BJ, Miller NE
Evaluation of effects of unmodified niacin on fasting and postprandial plasma lipids in normolipidemic men with hypoalphalipoproteinemia
Am J Med 1994; 97: 323-331
MRC General Practice Research Framework
Randomised controlled comparison of oestrogen versus oestrogen plus progestogen hormone replacement therapy in hysterectomised women
Br Med J. 1996; 312: 473-478

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Phamacokinetics

Mawer GE, Miller NE, Turnberg LA
Metabolism of amylobarbitone in patients with chronic liver disease
Br J Pharmacol 1972; 44:549-560
Hovorka R, Nanjee MN, Cooke CJ, Miller IP, Olszewski WL, Miller NE
Mass kinetics of apolipoprotein A-I in human interstitial fluid: after intravenous apolipoprotein A-I/lecithin discs in humans
J Lipid Res 2006; 47: 975-981

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Laboratory method development

Nanjee MN, Miller NE
Sequential microenzymatic assay of cholesterol, triglycerides and phospholipids in a single aliquot
Clin Chem. 1996; 42:915-926
Stocks J, Nanjee MN, Miller NE
Analysis of high density lipoprotein apolipoproteins by capillary zone and capillary SDS gel electrophoresis
J Lipid Res 1998;39:218-227
Stocks J, Miller NE
Capillary electrophoresis to monitor the oxidative modification of low density lipoproteins.
J Lipid Res 1998; 39:1305-1309
Kujiraoka T, Oka T, Ishihara M, Egashira T, Fujioka T, Saito E, Saito S, Miller NE, Hattori H
A sandwich enzyme-linked immunosorbent assay for human serum paraoxonase concentration
J Lipid Res 2000; 41:1358-1363
Oka T, Kujiraoka T, Ito M, Nagano M, Ishihara M, Iwasaki T, Egashira T, Miller NE, Hattori H
Measurement of human plasma phospholipid transfer protein by sandwich ELISA
Clin Chem. 2000; 46:1357-1364
Ishihara M, Kujiraoka T, Iwasaki T, Nagano M, Takano M, Ishi J, Tsuji M, Ide H, Miller IP, Miller NE, Hattori H
A sandwich enzyme-linked immunosorbent assay for human plasma
apolipoprotein A-V concentration
J Lipid Res 2005; 46: 2015-2022

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