2008-2018 Ten years’ service to the pharma and biotech industries

Who we are

Dr Irina P Miller Publications

Thrombosis, platelet function and haemostasis

Stepanova I P*, Domogatsky SP                                                               [*Previous name]
Device and thrombosis model in vitro
Bull Exper Biol Med 1994; 2: 194-197
Stepanova I P*, Tzybulskaya MB, Domogatsky SP
Antithrombotic effect of binding urokinase to the collagen substrate by means of bi-functional antibodies
Bull Exper Biol Med. 1994; 5: 504-507
Bashkov GV, Stepanova IP*, Domogatsky S P
Collagen-targeted antibodies inhibit platelet-dependent thrombosis in vivo
Thrombosis Research 1994; 74: 321-334
Miller GJ, Cooke CJ, Nanjee MN, Howarth DJ, Cooper JA, Stepanova IP*,
Morrissey JH, Miller NE
Factor VII activation, apolipoprotein A-I and reverse cholesterol transport: possible relevance for postprandial lipaemia
Thromb Haemostas 2002; 87: 477-482

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Lipoproteins

Shafi S, Stepanova IP*, Fitzsimmons C, Bowyer DE, Born GVR
Effect of reserpine on expression of the LDL receptor in liver and on plasma and tissue lipids, low-density lipoprotein and fibrinogen in rabbits in vivo
Atherosclerosis 2000; 149: 267-275
Shafi S, Stepanova IP*, Fitzsimmons C, Bowyer DE, Born GVR
Long-term low-dose treatment with reserpine of cholesterol-fed rabbits reduces cholesterol in plasma, non-high density lipoproteins and arterial walls
J Cardiovasc Pharmacol 2002; 40: 67-79
Kujiraoka T, Iwasaki T, Ishihara M, Ito M, Nagano M, Kawaguchi A, Takahashi S, Ishi J, Tsuji M, Egashira T, Stepanova IP*, Miller NE, Hattori H
Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus
J Lipid Res 2003; 44: 2006-2014
Kujiraoka T, Nanjee MN, Oka T, Ito M, Nagano M, Cooke CJ, Takahashi S, Olszewski WL, Wong J, Stepanova IP*, Hamilton RL, Egashira T, Hattori H, Miller NE
Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on LCAT, PLTP and CETP in plasma and peripheral lymph in humans
Arterioscler Thromb Vasc Biol 2003; 23: 1653-1659
Hattori H, Kujiraoka T, Egashira T, Saito E, Fujioka T, Takahashi S, Ito M, Cooper JA, Stepanova IP, Nanjee MN, Miller NE
Association of coronary heart disease with pre-beta HDL concentrations in Japanese men
Clin Chem 2004: 50: 589-595
Cooke CJ, Nanjee MN, Stepanova IP*, Olszewski WL, Miller NE
Variations in lipid and apolipoprotein concentrations in human leg lymph: Effects of posture and physical exercise
Atherosclerosis 2004; 173: 39-55
Kujiraoka T, Hattori H, Ito M, Nanjee MN, Ishihara M, Nagano M, Iwasaki T, Cooke CJ, Olszewski WL, Stepanova IP*, Egashira T, Miller NE
Effects of intravenous apolipoprotein A-I/phosphatidylcholine discs on paraoxonase and
platelet-activating factor acetylhydrolase in human plasma and tissue fluid

Atherosclerosis 2004; 176: 57-62
Miller NE, Nanjee MN, Miller IP, Brinton EA
Effects of intravenous apo A-I, HDLs and apo A-I/phospholipid discs on vascular metabolism and atherosclerosis in animals and humans
Current Medicinal Chemistry 2005; 5: 315-320
Ishihara M, Kujiraoka T, Iwasaki T, Nagano M, Schaap FG, Takano M, Takahashi S,
Ishi J, Tsuji M, Miller IP, Miller NE, Hattori H
A sandwich enzyme-linked immunosorbent assay for plasma apolipoprotein A-V concentration
J Lipid Res 2005: 46: 2015-2022
Kujiraoka T, Hattori H, Miwa Y, Ishihara M, Ueno T, Ishii J, Tsuji M, Iwasaki T, Sasaguri Y, Fujioka T, Saito S, Tsushima M, Maruyama T, Miller IP, Miller NE, Egashira T
Serum apo J in health, coronary heart disease and Type 2 diabetes mellitus
J Atheroscler Thromb 2006; 13:314-322
Talmud PJ, Cooper JA, Hattori H, Miller IP, Miller GJ, Humphries SE
The apolipoprotein A-V genotype and plasma apolipoprotein A-V and triglyceride levels: prospective risk of type 2 diabetes. Results from the Northwick Park Heart Study II
Diabetologia 2006; 49: 2337-40
Hovorka R, Nanjee MN, Cooke CJ, Miller IP, Olszewski WL, Miller NE
Mass kinetics of apolipoprotein A-I in human interstitial fluid: after intravenous apolipoprotein A-I/lecithin discs in humans
J Lipid Res 2006; 47: 975-981
Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, et al.
Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.
Am J Physiol - Metab Endocrinol 2011; 301:E659-E667.
Miller NE, Olszewski WL, Hattori H, Miller IP, Kujiraoka T, Oka T, et al.
Lipoprotein remodeling generates lipid-poor apolipoprotein AI particles in human interstitial fluid.
Am J Physiol - Metab Endocrinol 2013; 304: E321-E328.

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